Fig. 1.
Analgesic effect of resolvin D1 (RvD1) in the model of noncompressive lumbar disk herniation. With the application of nucleus pulposus to L5 dorsal root ganglion, the paw withdrawal threshold (PWT; n = 8/group) was significantly reduced from day 1 postsurgery to the last day in the vehicle group (each P < 0.001). Intrathecal injection of RvD1 (10 or 100 ng) for three successive days alleviated the mechanical allodynia in a dose-dependent manner. The mechanical allodynia was alleviated from day 3 to day 10 in the RvD1 (10 ng) group (each P < 0.001, except day 10: P = 0.023). Meanwhile, the mechanical allodynia was also alleviated significantly in the RvD1 (100 ng) group from day 2 to day 21 (each P < 0.001, except P = 0.018 on day 2). Data are expressed as mean ± SD (**P < 0.01 compared with sham group; #P < 0.05 compared with vehicle group; ##P < 0.01 compared with vehicle group).