Fig. 5.
Time to recovery of righting reflex (RORR) as a function of drug dose. Assuming first-order clearance kinetics, the data are plotted on a semilog scale. Drug dose is expressed on a milligram per kilogram basis for the propofol component of the emulsions (Diprivan, L3, B8, and F8). The x-axis intersection of the linear regression line is the calculated threshold dose for inducing LORR as a surrogate for unconsciousness.37 Sample sizes were Diprivan (28), L3 (29), B8 (27), and F8 (16). Note that the scale is different for D compared with A–C.