The changes of mean arterial pressure (MAP), heart rate, hematocrit, cardiac output, blood volume, and effective hepatic blood flow (HBF). The ratios were defined as the estimate of MAP, heart rate, hematocrit, cardiac output, blood volume, or effective HBF divided by the baseline estimate assessed before or at the start of propofol administration. The cardiac output, blood volume, and indocyanine green disappearance rate were determined using pulse dye densitogram. The effective hepatic blood flow was calculated as the blood volume multiplied by the indocyanine green disappearance rate. Each circle and whisker indicate the mean and SD of the variable. *Significant difference within the same group versus the baseline estimate (in B: P < 0.001 at 20 and 40 min for all groups; in C: P < 0.001 at 22.5 and 40 min for the hydroxyethyl starch [HES] solution and acetated Ringer’s [AR] solution groups; in D: P = 0.001 at 20 min and 0.009 at 40 min for the control group; in F: P < 0.001 at 20 and 40 min for the HES group). +Significant difference at the same time point versus the control group (in B: P = 0.001 at 40 min in the HES group; in C: P < 0.001 at 22.5 and 40 min in the HES group and at 22.5 min in the AR group, P = 0.001 at 40 min in the AR group; in F: P < 0.001 at 20 min and = 0.042 at 40 min in the HES group), or versus the AR group (in B: P = 0.021 at 40 min in the HES group).