Mean arterial pressure (mAP), heart rate (HR), and airway dynamic compliance (DC) measured before CW002, at injection (0 time) and 1, 3, 5, and 10 min after administration of the three highest doses. Triangles connected by dashed lines depict data for individual volunteers; open circles connected by solid lines represent mean ± SD for the cohort. HR was increased relative to baseline (P ≤ 0.05) during a range of time points after injection of both 0.10 and 0.14 mg/kg CW002 (designated by arrows).