Local field potential logarithmic power deviation from baseline (mean ± SD) at three different electrodes was plotted with ketamine dose. Power deviation was plotted for delta (panel 1), theta (panel 2), beta (panel 3), gamma 1 (panel 4, γ1), and gamma 2 (panel 5, γ2) frequency bands. Power at all frequency bands, except theta, and beta for some groups, showed an increase after 100 to 120 mg/kg ketamine. (A) At distal hippocampal electrode H1, significantly lower gamma 2 power is shown in either forebrain knockout or heterozygous knockdown mice as compared to wild-type mice. (B) At hippocampal alveus electrode H2, forebrain knockout compared to wild-type mice showed significantly higher beta power but lower gamma 2 power; heterozygous knockdown compared to wild-type or forebrain knockout mice showed lower beta but higher gamma 1 and gamma 2 power. (C) At the frontal cortex electrode, the spectra do not show significantly different power measures in any frequency band after ketamine. *P < 0.05, knockout versus wild-type; #P < 0.05, knockdown versus wild-type; +P < 0.05, knockdown versus knockout.