Simulations of the ketamine arterial (red) and venous (blue) plasma concentrations after the start of ketamine infusion toward a steady-state plasma concentration (arbitrarily set at 1.0). (A) Data from one study using a one-compartment ketamine model. (B) Data from seven studies using a two-compartment model. (C) Data from nine studies using a three-compartment model. The green line in C is the simulation based on the meta-analytical three-compartment model. (D) Simulated mean arterial (red) and venous (blue) with 95% CIs.