Malignant hyperthermia susceptible swine the size of adult humans were given halothane and succinylcholine at elapsed time 0. Within 15 min, arterial partial pressure of carbon dioxide exceeded 90 mmHg, and arterial pH was less than 6.9. Esophageal and axillary temperatures rapidly increased; rectal and forehead temperatures did not. Rectal and skin temperature therefore failed to identify lethal malignant hyperthermia crises. Modified from Iaizzo et al. with permission.³⁸