Fig. 5.
Structural model for the recirculatory pharmacokinetic model for ABP-700 and CPM-acid and the pharmacodynamic models for the Bispectral Index and the Modified Observer’s Assessment of Alertness/Sedation. The estimated value for each model parameter is shown in tables 1 and 2. BIS, bispectral index; CL, clearance; Ktransit, transit rate constant; ke0excite, effect-site rate constant for BIS disinhibition; ke0MOAA/S, effect-site rate constant for MOAA/S; ke0suppress, effect-site rate constant for BIS suppression; MOAA/S, Modified Observer’s Assessment of Alertness/Sedation; QCO, apparent cardiac output; QP, peripheral flow; QND, non-distributive flow.