Fig. 3.
Pain status per treatment group at Day 7 (secondary outcome). Median area under the curve (pain score-days) of average daily pain at Day 7 after placebo, ketamine, and ketamine/magnesium infusion. The red diamond represents the median, and each color point/line represents individual patient area under the curve per treatment group. Statistical analyses were carried out using random-effects models taking into account treatment group, sequence, and subject (as random effect). The carry-over effect was specified but dropped from the model because of lack of effect (for carry-over; i.e., the result was obtained with models excluding this parameter).