Effects of dimethyl fumarate treatment on antioxidants and oxidized DNA/RNA after spared nerve injury (SNI). Ipsilateral L4/5 dorsal root ganglia (DRG) were collected after 5 days of oral dimethyl fumarate (DMF) treatment (300 mg/kg; once per day) or vehicle (Veh), which began 14 days after SNI/sham surgery. Messenger RNA (mRNA) expression was quantified for enzymes involved in glutathione synthesis and activity (A) Gclm, (B) Gclc, (C) Gsr, (D) as well as total glutathione protein levels. mRNA for superoxide dismutase (SOD) isoforms (E) Sod1, (F) Sod2, and (G) total SOD activity were quantified. (H) Levels of 8-oxo-2-deoxyguanonsine (8-oxo-dG)/ 8-oxoguanine (8-oxo-G), a marker of DNA/RNA oxidative damage. Data are mean ± SD; *P < 0.05, **P < 0.01, ***P < 0.001; DRG from n = 6 rats/group.