Effects of dimethyl fumarate treatment on mitochondrial bioenergetics after spared nerve injury (SNI). Ipsilateral L4/5 dorsal root ganglia (DRG) were collected and dissociated after 5 days of oral dimethyl fumarate treatment (300 mg/kg; once per day) or vehicle, which began 14 days after SNI/sham surgery. (A) A summary of mitochondrial bioenergetics is presented, and (B) basal respiration, (C) adenosine triphosphate (ATP)-linked respiration (response to oligomycin), (D) maximal mitochondrial respiration (response to carbonyl cyanide-p-trifluoromethoxyphenylhydrazone [FCCP]), and (E) spare respiratory capacity (difference between maximal and basal oxygen consumption rate [OCR]) were quantified. Data are mean ± SD; *P < 0.05, **P < 0.01, ***P < 0.001; DRG neurons from n = 5 rats in the sham-dimethyl fumarate and SNI-dimethyl fumarate groups, n = 6 rats in the sham-vehicle group, and n = 7 rats in the SNI-vehicle group.