Fig. 1.
Combined pharmacokinetic model, consisting of a three-compartment model for the parent drug remimazolam, a two-compartment model for the metabolite CNS 7054, and a transit compartment for the formation of the metabolite. It is assumed that 100% of the eliminated amount of remimazolam enters the transit compartment. V1, 1M, central volumes of distribution; V2, 3, 2M, peripheral volumes of distribution; CL, CLM, elimination clearances; Q2, 3, 2M, intercompartmental clearances; KM, transit rate constant; D, dose.