Evoked potentials during wakefulness, loss of consciousness (LOC), anesthesia, and return of consciousness (ROC) versus performance return. (A–C) Evoked potentials (averaged for 600 ms) in primary somatosensory cortex (S1) for puff (A), sound (B), and no stimulus (C) during wakefulness (before the start of ketamine infusion, in black), LOC (immediately after LOC, in red), anesthesia (before the end of ketamine infusion, in blue), ROC (immediately after ROC, in pink), and performance return (immediately after performance return, in cyan). (D and E) Evoked potentials in ventral premotor area (PMv) for puff (C), sound (D), and no stimulus (E). In all panels, the traces show averaged voltage and 95% CI. In (A, B, D, and E), crosses indicate the Awake average for peak amplitude (with vertical SD bars) and time to peak (with horizontal SD bars). Stim, stimulus.