Fig. 4.
Vancomycin pharmacokinetic analysis using NONlinear Mixed Effect Modeling (NONMEM) software. Blue points are the measured serum concentrations. Blue lines are the population-predicted concentrations. Red lines are the individual predicted concentrations (post hoc predicted concentrations). (A) NONMEM analysis for the six piglets that received intravenous vancomycin: The biexponential decrease in serum concentrations fits both individual and population predicted concentrations with a low variability. (B) NONMEM analysis for the six piglets that received nebulized vancomycin: The biexponential decrease in serum concentrations fits both individual and population-predicted concentrations with a high variability.