Fig. 4.
The halogenated anesthetics have a cytoplasmic site of action. Relative activation of ryanodine receptor 2 (RyR2) by halothane or enflurane in the cytoplasmic (cyt) or luminal (lum) solutions. Experimental conditions and composition of vehicle solution are given in figure 2. *Significant difference from 1 (two-tailed, Student’s t test, **P < 0.01).