Vascular response after intradermal angiotensin II injection. (A) Mean changes (±SD) in skin perfusion (expressed as changes from baseline of arbitrary perfusion units [ΔPU]) in response to angiotensin II, as stratified by GNAQ genotypes (GC/GC, n = 5; GC/TT, n = 7; TT/TT, n = 6). P value represents comparison of genotypes from two-way ANOVA (Tukey multiple comparison test yielded significant results for GC/GC vs. TT/TT and GC/TT vs. TT/TT). (B) Dose–response curves of contraction of saphenous vein rings in response to increasing angiotensin II concentrations (1 nM to 1 μM) according to GNAQ genotypes (GC/GC, n = 12; GC/TT, n = 28; TT/TT, n = 10). Curves were drawn with the use of a nonlinear fit-model (±SD) and a polynomial third-order equation. P value represents comparison of genotypes from two-way ANOVA (*P = 0.01 for post hoc comparison for GC/GC vs. TT/TT).