Fig. 4. The involvement of adenosine A1receptors, KATPchannels, and p21ras(Ras) in the hypothermic preconditioning–induced acute phase of neuroprotection in rat cerebellar slices. Survival rate and morphologically intact rate of Purkinje cells are presented in A and B , respectively. Oxygen-glucose deprivation (OGD) was for 20 min at 37°C. Hypothermic preconditioning (HP, 33°C for 20 min) was applied 1 h before the OGD. 8-Cyclopentyl-1,3-dipropylxanthine (DPC), glibenclamide (G), or farnesyl protein transferase inhibitor III (FPT) was applied to slices for 20 min either during the hypothermia or during the corresponding period for slices that were not subjected to hypothermia. Dashes = no inhibitors were used. *P < 0.01 compared with OGD-only group. N = 6–8 for each experimental condition. •= lowest and highest rates; between lines = 95% interval of the data; inside boxes = 25–75% interval, including the median of the data.