Fig. 3. (Top ) Example of the fitted Paco2and concentration time course (same subject as shown in fig. 1). Dashed line = plasma concentration as predicted by the target controlled infusion device; open circles = prediction of plasma concentration based on Bayesian pharmacokinetic parameters (previously published pharmacokinetic model); filled circles = measured Paco2; dotted line = population prediction of Paco2; solid line = Bayesian prediction of Paco2. (Bottom ) Diagnostic plot (all subjects). Predictions of Paco2based on typical values (open circles ) and Bayesian parameter estimates (filled circles ) are plotted against measured Paco2.