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Fig. 3. Relative efficacies of benzodiazepine site ligands in α1L264Tβ2γ2Lγ-aminobutyric acid type A receptors. The bar chart depicts maximal efficacies (mean ± SD, n ≥ 3), scaled relative to both the maximal picrotoxin-inhibited current (ImaxPTX; left ordinate axis ) and the maximal γ-aminobutyric acid (GABA)–activated current (ImaxGABA; right ordinate axis ). FG7142, an inverse agonist, seems to have a negative efficacy because it reduces channel activity. DZ = diazepam; FLU = flumazenil; MDZ = midazolam.

Fig. 3. Relative efficacies of benzodiazepine site ligands in α¹L264Tβ²γ^2Lγ-aminobutyric acid type A receptors. The bar chart depicts maximal efficacies (mean ± SD, n ≥ 3), scaled relative to both the maximal picrotoxin-inhibited current (I^max^PTX; left ordinate axis ) and the maximal γ-aminobutyric acid (GABA)–activated current (I^max^GABA; right ordinate axis ). FG7142, an inverse agonist, seems to have a negative efficacy because it reduces channel activity. DZ = diazepam; FLU = flumazenil; MDZ = midazolam.

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