Figure 3. Effect of intrathecal administration of 100 micro gram rat hemoglobin (Hb) on the development of thermal hyperesthesia induced by the nerve constriction injury in the pretreatment study. The vehicle group is presented for comparison. Each point represents the mean + SEM of nine to ten rats. Ordinate difference score (DS); abscissa days after the nerve constriction injury. *P < 0.05 compared with presurgery (day- 0) value in the same group. #P < 0.05 compared with the vehicle group 3 and 7 days after the nerve injury.