Figure 1. Mean neuromuscular, heart rate, and blood pressure responses to various doses of 51W89 are shown on the left side of the figure. The data presented for doses at < 2 times the ED⁹⁵of 51W89 are described in another manuscript. [15] Neuromuscular and cardiovascular effects of atracurium (BW 33A)[3] from a previous study are shown on the right side of the figure. Although significant decreases in blood pressure and increases in heart rate are seen with doses greater or equal to 2 times the ED⁹⁵of atracurium, no significant changes are seen in heart rate or blood pressure after doses as large as 8 times the ED⁹⁵of 51W89.