Figure 4. Anesthetic washout after 67-89 min of 4% sevoflurane general anesthesia. The total wash-out intensity (closed circle) at each time is weighted by the percentage of T^2fastand T^2slowcomponents at that time, resulting in separate elimination kinetics for the T^2fast(open square) and T^2slow(open circle) components. The solid lines are best fit to the data with single- or double-exponential functions, yielding elimination rate constants: k^f= 0.053 plus/minus 0.004 min sup -1, k^s1= 0.046 plus/minus 0.009 min sup -1, and k^s2= 0.007 plus/minus 0.001 min sup -1.