Figure 7. Schematic representation of canine myocardium subjected to a 60-min coronary artery occlusion and reperfusion and then stained to identify the region of myocardial infarction (black shaded area) within the area of myocardium at risk for infarction (light gray shaded area). Isoflurane decreased the extent of myocardial infarction; the protective effect of isoflurane was equivalent to that produced by ischemic preconditioning and was abolished by glyburide pretreatment. *Significantly (P < 0.05) different from control.