Figure 4. Propofol loss of righting reflex for (inbred short-sleep [ISS] c/c x C57BL/6 c^2j/C) F¹s and for inbred long-sleep (ILS) and ISS mice coinjected with tyrosine. (A) ISS mice have the classical albino mutation, whereas the c^2jalbino mutation arose spontaneously in C57BL/6 at Jackson Laboratory. Therefore, F¹mice are identical at all loci except the albino locus, pigmented mice (black bars) are c/C, and albino mice (white bars) are c/c^2j. LORRs of females are significantly shorter than those of males by 1.3 min (P = 0.002, analysis of variance, two-tailed test). However, LORRs of albinos are not significantly shorter than those of pigmented mice (P = 0.35, analysis of variance, one-tailed test). (B) ILS (black bars) and ISS (white bars) mice coinjected with tyrosine (indicated as pr + tyr) also did not exhibit significant differences in LORR (P = 0.78, analysis of variance, two-tailed test) from controls at a concentration of tyrosine (200 mg/kg) previously shown to differentially alter ethanol-induced LORRs in LS and SS. [41]n indicates the number of mice (males and females) tested. Error bars indicate the SEM.