Figure 6. Modification of muscimol-induced chloride (Cl sup -) currents by different drugs is shown in this figure. Every cell was exposed to 10 micro Meter muscimol followed by muscimol with one of the drugs. All the data are normalized to the response obtained with 10 micro Meter muscimol alone. Note the differences in concentrations between ethanol and pentobarbital needed for a similar increase in Cl sup - current. Bicuculline as a competitive antagonist blocks the muscimol-induced Cl sup - current effectively (n = 8 for every subgroup). A significant difference is found in peak Cl sup - currents induced by a combination of muscimol with ethanol, 80% N2O, pentobarbital, or antagonist bicuculline compared with muscimol alone.
