![Fig. 5. Effect of simultaneous inhibition of both inositol triphosphate (IP3) and ryanodine receptor (RyR) channels on the intracellular Ca2+concentration ([Ca2+]i) response of intact airway smooth muscle (ASM) cells to halothane. In the presence of blocking concentrations of both Xestospongin D and ryanodine, halothane did not elevate [Ca2+]i, indicating that the effect of halothane on the sarcoplasmic reticulum is mediated entirely via the two receptor channels. MAC = minimum alveolar concentration.](https://asa2.silverchair-cdn.com/asa2/content_public/journal/anesthesiology/95/1/10.1097_00000542-200107000-00032/5/32ff5.png?Expires=1716519705&Signature=EFD20yFAV-TieE4ktLGS-NrvsF7YYnUqCVIptLmfhlZy571K~kVe0-8uDZPCfszkPVv5PAvEZ4cpUKWgrsDGUMl57yvarQxDYvz~bX7KV3Wr2d701bb06BknkMRi1PjwbS-aoMQkYQRVmyr5eQ1VfvOx4aqtu6m~guibK2hfA08n27K6z9dLI5iLfOxpIW9ljVNU04D-1CEzWhQUpfN16QfEK7t9W6eh1s0XpmlRcE-PcHAaYpTJpR2nEeMWggAJeGKA5AztktsqlsStIFf5va4gCIEwqBoROVpoNiZJaDpe9jl1vJxGLfS~dJzNZi6ZokkeZF0h-GZqBD6tulWczA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Fig. 5. Effect of simultaneous inhibition of both inositol triphosphate (IP3) and ryanodine receptor (RyR) channels on the intracellular Ca2+concentration ([Ca2+]i) response of intact airway smooth muscle (ASM) cells to halothane. In the presence of blocking concentrations of both Xestospongin D and ryanodine, halothane did not elevate [Ca2+]i, indicating that the effect of halothane on the sarcoplasmic reticulum is mediated entirely via the two receptor channels. MAC = minimum alveolar concentration.
