Fig. 1. Effects of bicuculline (A ) and strychnine (B ) on wide dynamic range (WDR) neurons in the absence of halothane are shown. Cumulative doses of intravenous bicuculline did not significantly change the mean neuronal response to receptive field stimulation by either low-intensity (receptive field [RF], brush) or noxious (pinch, 51°C) stimuli. Strychnine also failed to alter the mean response to noxious stimuli and the RF size. However, strychnine did increase the mean neuronal activity evoked by brush stimulation. Data are presented as mean ± SD. *P < 0.05 versus  0 mg/kg; (n = 9–11).