Table 2. Population Pharmacodynamic Estimates
Values are population estimate ± SE and 95% confidence intervals as derived from the NONMEM analysis. IMAXand QMAXare interaction parameters (see text): IMAXvalues greater than one indicate synergy, and IMAXvalues equal to one indicate additivity. C50,Rand C50,Pare extrapolated values.
λ= percent decrease at 1 ng/ml remifentanil and 1 μg/ml propofol; BIS = bispectral index; HR = heart rate; MAP = mean arterial pressure; S = slope of the hypercapnic ventilatory response; V̇55= ventilation at a fixed Petco2of 55 mmHg; V̇i= inspired minute ventilation obtained without any inspired carbon dioxide.