Fig. 2. Antiallodynic effects of intrathecal gabapentin (GBP) coadministered with normal saline (NS) or ruthenium red (RR). (A–C ) Time courses of antiallodynic effects of 30 (A ), 100 (B ), or 200 μg gabapentin (C ) in the absence (GBP + NS) or presence (GBP + RR) of 0.2, 2, or 20 ng ruthenium red. Effect of 200 ng ruthenium red on the postoperative withdrawal threshold is also shown (□, A ). *P < 0.05 versus  GBP + NS group (two-way analysis of variance with post hoc  Dunnett test). (D ) Dose–response curves of peak (60 min after injection) antiallodynic effects of gabapentin coadministered with normal saline, 0.2, 2, or 20 ng ruthenium red. *P < 0.05 versus  GBP + NS group (two-tailed Student t  test). Data are expressed as mean ± SEM with n indicating the number of rats tested in each group.

Fig. 2. Antiallodynic effects of intrathecal gabapentin (GBP) coadministered with normal saline (NS) or ruthenium red (RR). (A–C ) Time courses of antiallodynic effects of 30 (A ), 100 (B ), or 200 μg gabapentin (C ) in the absence (GBP + NS) or presence (GBP + RR) of 0.2, 2, or 20 ng ruthenium red. Effect of 200 ng ruthenium red on the postoperative withdrawal threshold is also shown (□, A ). *P < 0.05 versus  GBP + NS group (two-way analysis of variance with post hoc  Dunnett test). (D ) Dose–response curves of peak (60 min after injection) antiallodynic effects of gabapentin coadministered with normal saline, 0.2, 2, or 20 ng ruthenium red. *P < 0.05 versus  GBP + NS group (two-tailed Student t  test). Data are expressed as mean ± SEM with n indicating the number of rats tested in each group.

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