Fig. 3. Antiallodynic effects of intrathecal gabapentin (GBP) coadministered with normal saline (NS) or spermine (SP). (A–C ) Time courses of antiallodynic effects of 30 (A ), 100 (B ), or 200 μg gabapentin (C ) in the absence (GBP + NS) or presence (GBP + SP) of 30 or 60 μg spermine. Effects of 30 and 60 μg spermine on the postoperative withdrawal threshold are also shown (▪ and □, respectively, A ). *P < 0.05 versus  GBP + NS group (two-way analysis of variance with post hoc  Dunnett test). (D ) Dose–response curves of peak (60 min after injection) antiallodynic effects of gabapentin coadministered with normal saline, 30 or 60 μg spermine. *P < 0.05 versus  GBP + NS group (two-tailed Student t  test). Data are expressed as mean ± SEM with n indicating the number of rats tested in each group.

Fig. 3. Antiallodynic effects of intrathecal gabapentin (GBP) coadministered with normal saline (NS) or spermine (SP). (A–C ) Time courses of antiallodynic effects of 30 (A ), 100 (B ), or 200 μg gabapentin (C ) in the absence (GBP + NS) or presence (GBP + SP) of 30 or 60 μg spermine. Effects of 30 and 60 μg spermine on the postoperative withdrawal threshold are also shown (▪ and □, respectively, A ). *P < 0.05 versus  GBP + NS group (two-way analysis of variance with post hoc  Dunnett test). (D ) Dose–response curves of peak (60 min after injection) antiallodynic effects of gabapentin coadministered with normal saline, 30 or 60 μg spermine. *P < 0.05 versus  GBP + NS group (two-tailed Student t  test). Data are expressed as mean ± SEM with n indicating the number of rats tested in each group.

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