Fig. 6. Transcapillary flux in one sheep during the protocol with hemorrhage 0–5 min 300 ml followed by infusion of 25 ml/kg of 0.9% saline between 5 and 25 min ( between dotted lines ). Filled squares represent the mass balance calculation of influx to the plasma (positive values) and efflux from the plasma (negative values), respectively. The line represents the flux of the central compartment V C predicted by the volume turnover model as the sum of volume change equilibration between V C and V T and by other mechanisms represented by Cl bleed . Note that V C is not equal to plasma volume regardless of the strong correlation between the flux over the two volumes.