Fig. 2. Volatile general anesthetic resistance not due to enhancement of locomotion or neurotransmitter release. ( A ) Locomotion rates of age-synchronized young adults from strains transformed with pTXmd130(MC168), pTX1–158(MC150, MC151, and MC152), and pTX1–106(MC158, MC159, and MC139) were measured by the number of body bends/min and normalized to concurrent wild-type N2 values. Values are mean ± SEM of more than 10 animals. The hyperactive locomotion mutant, goa-1(sy192) , is shown as a positive control. 11,* Significantly different from 100% at P < 0.01, two-tailed t test. ( B ) Aldicarb sensitivity of a subset of truncated syntaxin transformants. The fraction of animals moving after various incubation times on agar plates containing 0.35 mm aldicarb. Each point represents the mean ± SEM of triplicate measurements of at least 30 animals/measurement. The aldicarb-hypersensitive/isoflurane-resistant strain slo-1(js379) and the aldicarb-resistant/isoflurane-resistant unc-64(md130) strain are shown for comparison. 8,9,26