Fig. 3. Vasodilator responses to ( A ) donepezil (10−9–10−8m) and to ( B ) sodium nitroprusside (3 × 10−5to 3 × 10−3m) in the cerebral parenchymal arterioles of neuronal nitric oxide synthase knock-out and control mice. Baseline internal diameters of arterioles were ( A ) 4.2 ± 0.4 and 5.3 ± 0.8 μm and ( B ) 5.5 ± 0.7 and 4.8 ± 0.6 for control and neuronal nitric oxide synthase knock-out mice, respectively. Data are shown as mean ± SD. Difference between the arterioles of control and neuronal nitric oxide synthase knock-out mice was statistically significant (* P < 0.05).
