Fig. 5. Changes over time in the severity of seizure activity in animals that experienced seizures after administration of Sazetidine-A (2 mg/kg; 0%) and epibatidine (5–10 μg/kg; 60% and 66%, respectively). Seizure scores were calculated based on the Racine scale: stage 1, facial movements; stage 2, rhythmic head movements, head nodding; stage 3, unilateral forelimb clonus; stage 4, bilateral forelimb clonus and rearing; stage 5, falling and clonic convulsion. Data are presented as mean ± SEM.