Fig. 5. Disruption of the blood–brain barrier with intracarotid mannitol. The figure shows the disruption of the blood–brain barrier by intracarotid injection of mannitol (25%) in New Zealand White rabbits as evidenced by the distribution of 2% Evans blue dye: 2-ml (  A ), 4-ml (  B ), 6-ml (  C ), and 8-ml (  D ) mannitol bolus injected through the carotid artery in 1 min. From Wang  et al. 83; used with permission.