Fig. 4. Visual predictive check of the observed and predicted recovery time (time from sugammadex administration to 90% recovery of the ratio between the first and fourth twitch height after train-of-four stimulation) of rocuronium (0.6 mg/kg)-induced blockade after administration of ( A ) sugammadex 1, 2, 4, 6, or 8 mg/kg at 3 min; ( B ) sugammadex 1, 2, 4, 6, or 8 mg/kg at 5 min; and ( C ) sugammadex 1, 2, 4, 6, or 8 mg/kg at 15 min. The open symbols represent the observed recovery time in validation study 2. The median of the observed recovery time is shown by the closed box symbol . The horizontal line represents the uncertainty (95% CIs) in the observed median derived by bootstrap analysis. The solid line shows the predicted median of the recovery time and the variability in the predicted recovery time for 50% of the population is represented by the dashed lines .