Fig. 5. Visual predictive check of the observed and predicted recovery time (time from sugammadex administration to 90% recovery of the ratio between the first and fourth twitch height after train-of-four [TOF] stimulation) after administration of (  A ) 0.6 mg/kg rocuronium or (  B ) 0.1 mg/kg vecuronium followed by sugammadex at reappearance of the second twitch (T²) after TOF stimulation. The  open symbols represent the observed recovery time in validation study 1 (  A ) and validation study 3 (  B ), respectively. The  closed box symbol shows the median of the observed recovery time. The  horizontal line represents the uncertainty (95% CIs) in the observed median, derived by bootstrap analysis. The  solid line shows the predicted median of the recovery time, and the variability in the predicted recovery time for 50% of the population is represented by the  dashed lines .