Fig. 3. The α-1 antagonist prazosin restores clonidine analgesia in α-2C knockout mice. Total pain scores in α-2C knockout mice after administration of vehicle (DMSO), sulprostone, prazosin 100 ng/kg intraperitoneally, sulprostone plus prazosin, and sulprostone following clonidine pretreatment, with or without prazosin. The effect of prazosin alone was not significantly different from vehicle. α-1 blockade by prazosin restored clonidine analgesia in α-2C knockout mice with sulprostone-induced allodynia. Clon = clonidine; DMSO = dimethyl sulfoxide; Pra = prazosin; Sulp = sulprostone. **  P < 0.01, ***  P < 0.001  versus sulprostone, N = 6 mice per group. 

Fig. 3. The α-1 antagonist prazosin restores clonidine analgesia in α-2C knockout mice. Total pain scores in α-2C knockout mice after administration of vehicle (DMSO), sulprostone, prazosin 100 ng/kg intraperitoneally, sulprostone plus prazosin, and sulprostone following clonidine pretreatment, with or without prazosin. The effect of prazosin alone was not significantly different from vehicle. α-1 blockade by prazosin restored clonidine analgesia in α-2C knockout mice with sulprostone-induced allodynia. Clon = clonidine; DMSO = dimethyl sulfoxide; Pra = prazosin; Sulp = sulprostone. **  P < 0.01, ***  P < 0.001  versus sulprostone, N = 6 mice per group. 

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