Fig. 3. Effects of calcitonin gene-related peptide (CGRP), capsazepine (CPZ), CGRP(8–37), denervation of primary sensory nerves, and indomethacin (intramuscular) on renal ischemia/reperfusion (I/R)-induced increases in renal 6-keto-prostaglandin F1α(6-keto-PGF1α) levels 1 h after I/R. CPZ (20 mg/kg) was administered subcutaneously 30 min before renal ischemia, CGRP(8–37) (0.1 mg/kg) was administered intravenously 30 min before renal ischemia, denervation of primary sensory nerves was accomplished by high-dose capsaicin, and intramuscular (5 mg/kg) was administered subcutaneously 30 min before renal ischemia. Data are expressed as mean ± SD values of six animals. * P < 0.05 versus sham-operated group; † P < 0.05 versus vehicle-treated group.