Fig. 6. Effects of calcitonin gene–related peptide (CGRP), capsazepine (CPZ), CGRP(8–37), denervation of primary sensory nerves, indomethacin (intramuscular), and iloprost on renal ischemia/reperfusion (I/R)–induced increase in renal vascular permeability 6 h after the injury. Renal vascular permeability was assessed by measuring extravasation of Evans blue dye. CPZ (20 mg/kg) was administered subcutaneously 30 min before renal ischemia, CGRP(8–37) (0.1 mg/kg) was administered intravenously 30 min before renal ischemia, denervation of primary sensory nerves was accomplished by high-dose capsaicin, and intramuscular (5 mg/kg) was administered subcutaneously 30 min before renal ischemia. Iloprost (100 ng · kg−1· min−1) was infused continuously for 3 h after the onset of renal reperfusion. Data are expressed as mean ± SD values of six animals. * P < 0.05 versus sham-operated group; † P < 0.05 versus vehicle-treated group.