Fig. 7. Effects of calcitonin gene–related peptide (CGRP), capsazepine (CPZ), CGRP(8–37), denervation of primary sensory nerves, indomethacin (intramuscular), and iloprost on renal ischemia/reperfusion (I/R)–induced increases in renal tissue levels of myeloperoxidase (MPO) activity ( A ), cytokine-induced neutrophil chemoattractant (CINC) ( B ), and tumor necrosis factor (TNF)-α ( C ). Renal tissue levels of MPO activity were determined 6 h after renal I/R; CINC and TNF-α were determined 3 h after renal I/R. CPZ (20 mg/kg) was administered subcutaneously 30 min before renal ischemia, CGRP(8–37) (0.1 mg/kg) was administered intravenously 30 min before renal ischemia, denervation of primary sensory nerves was accomplished by high-dose capsaicin, and intramuscular (5 mg/kg) was administered subcutaneously 30 min before renal ischemia. Iloprost (100 ng · kg-1· min-1) was infused continuously for 3 h after the onset of renal reperfusion. Data are expressed as mean ± SD values of six animals. * P < 0.05 versus sham-operated group; † P < 0.05 versus vehicle-treated group.