Fig. 4. Isoflurane postconditioning produced concentration-dependent increases in cardiac function in Langendorff-perfused wild-type hearts subjected to 30 min of global ischemia followed by 2 h of reperfusion. (A ) Left ventricular developed pressure (LVDP); (B ) +dP/dt (maximum rate of increase of LVDP); (C )−dP/dt (maximum rate of decrease of LVDP); (D ) LV end-diastolic pressure (LVEDP); (E ) coronary flow; (F ) heart rate. ISO0.5= 0.5 minimum alveolar concentration of isoflurane; ISO1.0= 1.0 minimum alveolar concentration of isoflurane; ISO1.5= 1.5 minimum alveolar concentration of isoflurane. *P < 0.05 versus control (n = 7–8 hearts/group).