Fig. 3. The β3(N265M) mutation largely attenuates the effects of etomidate on brain electrical activity observed in wild-type mice. (A ) In β3(N265M) mice, hypnosis lasts less than 10 min, compared with approximately 40 min in wild types. (B ) Local field potential recordings before and after etomidate injection show that in mutant mice, bolus injection of 10 mg/kg etomidate does not evoke isoelectric brain activity. RoRR = recovery of righting reflexes.