Fig. 2. Etomidate-induced increase in the holding current in CA1 pyramidal neurons. ( A ) Current traces indicate an inward tonic current with etomidate application. The etomidate increase in the holding current is reduced by 73.18 ± 9.05% with L-655,708 application. Bicuculline was applied at the end of the recording to reveal the total tonic conductance. ( B ) The all-point histograms for the current traces and the shifts in the holding current are shown. ( C ) Pooled data showing the relative changes in the holding current with etomidate, L-655,708, and bicuculline application. ( D ) The percentage of the block by L-655,708 and bicuculline on the total etomidate-induced tonic current is shown. Short forms in the figure refer to artificial cerebral spinal fluid (aCSF), etomidate (Etom), L-655,708 (L-6), and bicuculline (Bic). * Significantly different from the etomidate group .