Fig. 10 . Isoflurane exposure increases sphingosine kinase (SK) 1 activity and sphingosine-1-phosphate (S1P) formation. (A ) Relative SK1 activity (fold over pentobarbital group) from intestines of sham mice exposed to 4 h of pentobarbital or isoflurane (n = 6 per group). (B ) Formation of S1P (fold over pentobarbital group) from the intestines of sham mice exposed to 4 h of pentobarbital or isoflurane (n = 4 per group). *P < 0.05 versus the pentobarbital group. Data are presented as the mean ± SEM.