Fig. 4.  Effect of intrathecal DL-threo-β-benzyloxyaspartate (TBOA) on thermal hyperalgesia induced by complete Freund's adjuvant. Intrathecal TBOA significantly and dose-dependently attenuated the induced decrease in ipsilateral paw withdrawal latency at 6 (A ) and 24 (B ) h after injection with complete Freund's adjuvant. TBOA at the doses used (1, 5, or 10 μg/10 μl) did not affect basal paw withdrawal response to thermal stimulation on the contralateral side (A  and B ). *P < 0.05 or **P < 0.01 versus  saline (0).

Fig. 4.  Effect of intrathecal DL-threo-β-benzyloxyaspartate (TBOA) on thermal hyperalgesia induced by complete Freund's adjuvant. Intrathecal TBOA significantly and dose-dependently attenuated the induced decrease in ipsilateral paw withdrawal latency at 6 (A ) and 24 (B ) h after injection with complete Freund's adjuvant. TBOA at the doses used (1, 5, or 10 μg/10 μl) did not affect basal paw withdrawal response to thermal stimulation on the contralateral side (A  and B ). *P < 0.05 or **P < 0.01 versus  saline (0).

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