Fig. 1. Concurrent noxious stimulation with CFA attenuates ketamine-induced caspase-3 activation. (A ) Western blot from postnatal day 7 brain protein lysates demonstrates that intraplantar CFA affects ketamine-induced (B ) changes in cleaved caspase-3 expression (n = 6, ***P < 0.01 compared with control, *P < 0.05 ketamine + CFA vs.  ketamine). Data are presented as mean ± SE. CFA = complete Freund's adjuvant; KET = ketamine.