Fig. 3. Concurrent noxious stimulation attenuates ketamine-induced increases in TUNEL positive cells. Immunohistochemistry with antibody to cleaved caspase-3 on S1 cortical sections from P7 rat pups (A ) control, (B ) CFA, (C ) KET + CFA and (D ) KET (scale bar = 10 μm). (E ) Quantitation of terminal deoxynucleotidyl-transferase mediated 2′-deoxyuridine 5′-triphosphate nick end labeling (TUNEL) positive cells in the ACC, S1, and S2 regions of the P7 brain. ***P < 0.01 compared with saline. Values are means ± SE (n = 6). CFA = complete Freund's adjuvant; KET = ketamine.

Fig. 3. Concurrent noxious stimulation attenuates ketamine-induced increases in TUNEL positive cells. Immunohistochemistry with antibody to cleaved caspase-3 on S1 cortical sections from P7 rat pups (A ) control, (B ) CFA, (C ) KET + CFA and (D ) KET (scale bar = 10 μm). (E ) Quantitation of terminal deoxynucleotidyl-transferase mediated 2′-deoxyuridine 5′-triphosphate nick end labeling (TUNEL) positive cells in the ACC, S1, and S2 regions of the P7 brain. ***P < 0.01 compared with saline. Values are means ± SE (n = 6). CFA = complete Freund's adjuvant; KET = ketamine.

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