Fig. 1. The effect of mast cell previous depletion or membrane stabilization on postoperative nociception in mice. Time-response curves of the pre-administration of the compound 48/80 (A , 1, 3, 10, and 10 µg/paw, intraplantar [i.pl.]), cromoglycate (B , 200 µg/paw, i.pl.) or ketotifen (C , 10 mg/kg, per os [p.o]) on mechanical hyperalgesia after plantar surgery in mice. Vertical bars  represent the means + SEM (A , C , n = 6 to all groups; B , n = 7 to phosphate buffered saline [PBS] and n = 6 to cromoglycate groups). *P < 0.05, **P < 0.01 and ***P < 0.001 when compared to the PBS-treated group; ##P < 0.001 when compared to baseline (B ); two-way ANOVA followed by Bonferroni correction test.