Fig. 2. Effects of medetomidine on locomotor activity (A ), duration of LORR (B ) and body temperature (C ) in α3KO and wt mice. (A ) Locomotor activity was comparable in both genotypes at all medetomidine doses over the whole 60 min time period (insert) and looking at 5-min time bins. (B ) Duration of LORR was significantly increased in α3KO mice by 250 µg/kg medetomidine compared with WT mice (Sheffé post hoc  tests). (C ) Body temperature was comparable between α3KO mice and WT mice. Data represent the mean ± SEM; n = 9 per genotype. KO = knockout; LORR = loss of righting reflex; WT = wild type.